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Background:The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression ofThis receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind toThis receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
