Name: Recombinant CD16 Fc-Fused Nanobody (VF0534)
SKU: WN0117
Price: 365 USD
Availability: InStock

Product details

Background:This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses.This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded byThis gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations inThis gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq,

Specifications

Size	100μL
Target	CD64
Reactivity	Human
Applications	FC, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	Please check the information on the tube
Clonality
Clone Number	VF0398
Immunogen	Purified recombinant Human CD16
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD16 protein.
Gene Name	FCGR3A CD16A FCG3 FCGR3 IGFR3
Protein Name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Other Name	CD 16 antibody; / CD 16a antibody; / CD16 antibody; / CD16a antibody; / CD16a antigen antibody; / CD16B antibody; / CD16b antigen antibody; / Fc fragment of IgG antibody; / Fc fragment of IgG low affinity IIIa receptor; / CD16; / antibody; / Fc fragment of IgG low affinity IIIa receptor antibody; / Fc fragment of IgG receptor IIIa antibody; / Fc fragment of IgG; / low affinity III; / receptor; / CD16; / antibody; / Fc fragment of IgG; / low affinity III; / receptor for; / CD16; / antibody; / Fc fragment of IgG; / low affinity IIIa; / receptor; / CD16; / antibody; / Fc fragment of IgG; / low affinity IIIa; / receptor; / CD16a; / antibody; / Fc fragment of IgG; / low affinity IIIa; / receptor for antibody; / Fc fragment of IgG; / low affinity IIIb; / receptor; / CD16b; / antibody; / Fc fragment of IgG; / low affinity IIIb; / receptor for; / CD16; / antibody; / Fc gamma R3 antibody; / Fc gamma receptor III 2; / CD 16; / antibody; / Fc gamma receptor III A antibody; / Fc gamma receptor IIIA antibody; / Fc gamma receptor IIIb; / CD 16; / antibody; / Fc gamma RIII alpha antibody; / Fc gamma RIII antibody; / Fc gamma RIII beta antibody; / Fc gamma RIIIa antibody; / Fc gamma RIIIb antibody; / Fc of IgG antibody; / Fc-gamma receptor III2; / CD 16; / antibody; / Fc-gamma receptor III2; / CD16; / antibody; / Fc-gamma receptor IIIb; / CD16; / antibody; / Fc-gamma RIII antibody; / Fc-gamma RIII-alpha antibody; / Fc-gamma RIIIa antibody; / FCG 3 antibody; / FCG3 antibody; / FCG3A_HUMAN antibody; / FCgammaRIIIA antibody; / FCGR 3 antibody; / FCGR 3A antibody; / FCGR3 antibody; / FCGR3A antibody; / FCGR3A protein antibody; / FCGRIII antibody; / FCGRIII-2 antibody; / FcR 10 antibody; / FcR-10 antibody; / FcR10 antibody; / FcRIII antibody; / FcRIIIa antibody; / IGFR 3 antibody; / IGFR3 antibody; / IgG Fc receptor III 1 antibody; / IgG Fc receptor III 2 antibody; / IgG Fc receptor III-2 antibody; / IMD20 antibody; / immunoglobulin G Fc receptor III antibody; / immunoglobulin G Fc receptor III-2 antibody; / Low affinity IIIa receptor antibody; / Low affinity immunoglobulin gamma Fc region receptor III A antibody; / Low affinity immunoglobulin gamma Fc region receptor III-A antibody; / Low affinity immunoglobulin gamma Fc region receptor IIIB antibody; / neutrophil-specific antigen NA antibody
Species	Human
Gene ID	2209
Uniprot	P08637,
Species.1	Mouse
Gene ID.1	14129
Uniprot.1	P26151
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Single-pass type I membrane protein . Secreted . Exists also as a soluble receptor. .
Tissue Expression	Monocyte/macrophage specific.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia;Human Diseases >> Immune disease >> Systemic lupus erythematosus
Research Areas	>>Phagosome; / >>Osteoclast differentiation; / >>Neutrophil extracellular trap formation; / >>Hematopoietic cell lineage; / >>Fc gamma R-mediated phagocytosis; / >>Leishmaniasis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia; / >>Systemic lupus erythematosus
Function	Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.,miscellaneous:Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the Ser-203 in III-B determines the GPI-anchoring.,online information:FCGR3A mutation db,polymorphism:Isoform Val-157 shows a higher binding capacity of IgG1, IgG3 and IgG4 compared with isoform Phe-157. Alleles Leu-66 and Phe-157, and alleles His-66 / Arg-66 and Val-157 are in linkage desequilibrium.,PTM:Glycosylated. Contains high mannose- and complex-type oligosaccharides.,PTM:The soluble form is produced by a proteolytic cleavage.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Exists also as a soluble receptor.,subunit:Exists as a hetero-oligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1.,tissue specificity:Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.,

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Recombinant CD16 Fc-Fused Nanobody (VF0534)

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Recombinant CD16 Fc-Fused Nanobody (VF0534)

Product details

Specifications

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