Recombinant CD166 Fc-Fused Nanobody (VF0357)
Ucallm_WN0130
$365.00
Product details
Background:This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
Specifications
| Size | 100μL |
| Target | CD166 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0407 |
| Immunogen | Purified recombinant Human CD166 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD166 protein. |
| Gene Name | ALCAM MEMD |
| Protein Name | CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166) |
| Other Name | ALCAM; / MEMD; / CD166 antigen; / Activated leukocyte cell adhesion molecule; / CD166 |
| Species | Human |
| Gene ID | 214 |
| Uniprot | Q13740 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). .; [Isoform 3]: Secreted . |
| Tissue Expression | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | Domain:The CD6 binding site is located in the N-terminal Ig-like domain.,Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines., |
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