Name: Recombinant CD184 Fc-Fused Nanobody (VF0339)
SKU: WN0138
Price: 365 USD
Availability: InStock

Product details

Background:CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lymphopoiesis and myelopoiesis, cardiogenesis, blood vessel formation, and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2.

Specifications

Size	100μL
Target	CD184
Reactivity	Human
Applications	ELISA
MW(Calculated)
MW(Observed)
Host Species
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration	Please check the information on the tube
Clonality
Clone Number	VF0324
Immunogen	Purified recombinant Human CD184
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD184 protein.
Gene Name	CXCR4
Protein Name	C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
Other Name	CXCR4; / FB22; / HM89; / LAP3; / LCR1; / NPYR; / WHIM; / CD184; / LAP-3; / LESTR; / NPY3R; / NPYRL; / WHIMS; / HSY3RR; / NPYY3R; / WHIMS1; / D2S201E; / C-X-C chemokine receptor type 4 antibody; / CD184 antibody; / CD184 antigen antibody; / Chemokine; / C X C motif; / receptor 4 antibody; / Chemokine CXC Motif Receptor 4 antibody; / CXC-R4 antibody; / CXCR-4 antibody; / CXCR4 antibody; / CXCR4_HUMAN antibody; / D2S201E antibody; / FB22 antibody; / Fusin antibody; / HM89 antibody; / HSY3RR antibody; / LAP 3 antibody; / LAP3 antibody; / LCR1 antibody; / LESTR antibody; / Leukocyte derived seven transmembrane domain receptor antibody; / Leukocyte-derived seven transmembrane domain receptor antibody; / Lipopolysaccharide associated protein 3 antibody; / Neuropeptide Y receptor Y3 antibody; / NPY3R antibody; / NPYR antibody; / NPYRL antibody; / NPYY3 antibody; / NPYY3R antibody; / Probable G protein coupled receptor lcr1 homolog antibody; / SDF 1 receptor antibody; / SDF-1 receptor antibody; / SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody; / Stromal cell derived factor 1 receptor antibody; / Stromal cell-derived factor 1 receptor antibody; / WHIM antibody; / WHIMS antibody
Species	Human
Gene ID	7852
Uniprot	P61073
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane; Multi-pass membrane protein . Cell junction. Early endosome. Late endosome. Lysosome. In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Tissue Expression	Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
Signaling_pathway	Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Organismal Systems >> Immune system >> Chemokine signaling pathway;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
Research Areas
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

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Recombinant CD184 Fc-Fused Nanobody (VF0339)

Product details

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Recombinant CD184 Fc-Fused Nanobody (VF0339)

Product details

Specifications

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