Recombinant CD185 Fc-Fused Nanobody (VF0654)
Ucallm_WN0149
$365.00
Product details
Background:CD185, also known as CXCR5, is a 42 kD G-protein coupled receptor with seven transmembrane regions. CXCR5 is expressed by mature B cells, follicular helper T cells, Burkitt’s lymphoma cells and a subset of neurons, and mediates cell migration to the B cell follicles in the secondary lymphoid organs. The ligand of CXCR5 is CXCL13 (BLC).
Specifications
| Size | 100μL |
| Target | CD185 |
| Reactivity | Human |
| Applications | FC, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0333 |
| Immunogen | Purified recombinant Human CD185 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD185 protein. |
| Gene Name | CXCR5 BLR1 MDR15 |
| Protein Name | C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185) |
| Other Name | BLR1; / MDR15; / BLR 1 antibody; / BLR1 antibody; / Burkitt lymphoma receptor 1 antibody; / Burkitt lymphoma receptor 1 GTP binding protein antibody; / Burkitt lymphoma receptor 1; / GTP binding protein; / chemokine; / C-X-C motif; / receptor 5; / antibody; / C X C chemokine receptor type 5 antibody; / C-X-C chemokine receptor type 5 antibody; / CD 185 antibody; / CD185 antibody; / CD185 antigen antibody; / Chemokine; / C-X-C motif; / receptor 5 antibody; / Chemokine C X C motif receptor 5 antibody; / Chemokine CXC motif receptor 5 antibody; / Chemokine receptor 5 antibody; / CXC chemokine receptor type 5 antibody; / CXC R5 antibody; / CXC-R5 antibody; / CXCR 5 antibody; / CXCR-5 antibody; / Cxcr5 antibody; / CXCR5_HUMAN antibody; / MDR 15 antibody; / MDR-15 antibody; / MDR15 antibody; / MGC117347 antibody; / Monocyte derived receptor 15 antibody; / Monocyte-derived receptor 15 antibody |
| Species | Human |
| Gene ID | 643 |
| Uniprot | P32302 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | |
| Function | Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. |
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