Recombinant CD26 Fc-Fused Nanobody (VF0210)
Ucallm_WN0211
$365.00
Product details
Background:The protein encoded byThis gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD26 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0093 |
| Immunogen | Purified recombinant Human CD26 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD26 protein. |
| Gene Name | DPP4 ADCP2 CD26 |
| Protein Name | Dipeptidyl peptidase 4 (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) |
| Other Name | DPP4; / ADCP2; / CD26; / Dipeptidyl peptidase 4; / ADABP; / Adenosine deaminase complexing protein 2; / ADCP-2; / Dipeptidyl peptidase IV; / DPP IV; / T-cell activation antigen CD26; / TP103; / CD26; / CD26 nanobody |
| Species | Human |
| Gene ID | 1803 |
| Uniprot | P27487 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Dipeptidyl peptidase 4 soluble form]: Secreted . Detected in the serum and the seminal fluid. .; Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction . Membrane raft . Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). . |
| Tissue Expression | Lymphoid specific. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.,Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation.,online information:Dipeptidyl peptidase-4 entry,PTM:The soluble form (SDPP) derives from the membrane form (MDPP) by proteolytic processing.,similarity:Belongs to the peptidase S9B family. DPPIV subfamily.,subunit:Homodimer or heterodimer with Seprase (FAP).,tissue specificity:Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon., |
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