Recombinant CD27 Fc-Fused Nanobody (VF0511)
Ucallm_WN0230
$365.00
Product details
Background:CD27 molecule(CD27) Homo sapiens The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process ofThis receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind toThis receptor and is thought to play an important role in the apoptosis induced byThis receptor. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD27 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0383 |
| Immunogen | Purified recombinant Human CD27 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD27 protein. |
| Gene Name | CD27 TNFRSF7 |
| Protein Name | CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27) |
| Other Name | CD 27 antibody; / CD27 antibody; / CD27 antigen antibody; / CD27 molecule antibody; / CD27_HUMAN antibody; / CD27L receptor antibody; / LPFS2 antibody; / MGC20393 antibody; / OTTHUMP00000238557 antibody; / S152 antibody; / T cell activation antigen CD27 antibody; / T cell antivation antigen S152 antibody; / T-cell activation antigen CD27 antibody; / T14 antibody; / TNFRSF 7 antibody; / TNFRSF7 antibody; / TNFSF7 antibody; / Tp 55 antibody; / Tp55 antibody; / Tumor necrosis factor receptor superfamily member 7 antibody; / CD27 nanobody |
| Species | Human |
| Gene ID | 939 |
| Uniprot | P26842 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | |
| Function | Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. |
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