Recombinant CD279/PD1 Fc-Fused Nanobody (VF0612)
Ucallm_WN0256
$365.00
Product details
Background:This gene encodes a cell surface membrane protein of the immunoglobulin superfamily.This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression ofThis gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient forThis gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest thatThis gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | PD1 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0356 |
| Immunogen | Purified recombinant Human PD1 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD279/PD1 protein. |
| Gene Name | PDCD1 PD1 |
| Protein Name | Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) |
| Other Name | CD279 antibody; / CD279 antigen antibody; / hPD 1 antibody; / hPD l antibody; / hPD-1 antibody; / hSLE1 antibody; / PD 1 antibody; / PD-1 antibody; / PD1 antibody; / PDCD 1 antibody; / PDCD1 antibody; / PDCD1_HUMAN antibody; / Programmed cell death 1 antibody; / Programmed cell death 1 protein antibody; / Programmed cell death protein 1 antibody; / Protein PD 1 antibody; / Protein PD-1 antibody; / SLEB2 antibody; / Systemic lupus erythematosus susceptibility 2 antibody; / CD279 nanobody; / PD1 nanobody |
| Species | Human |
| Gene ID | 5133 |
| Uniprot | Q15116 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer., |
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