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Background:CD300e molecule(CD300E) Homo sapiens This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
| Size | 100μL |
| Target | CD300e |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0086 |
| Immunogen | Purified recombinant Human CD300e |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD300e protein. |
| Gene Name | CD300E CD300LE CLM2 CMRF35A5 IREM2 |
| Protein Name | CMRF35-like molecule 2 (CLM-2) (CD300 antigen-like family member E) (CMRF35-A5) (Immune receptor expressed on myeloid cells 2) (IREM-2) (Polymeric immunoglobulin receptor 2) (PIgR-2) (PIgR2) (Poly-Ig receptor 2) (CD antigen CD300e) |
| Other Name | CMRF35-like molecule 2; / CLM-2; / CD300 antigen-like family member E; / CMRF35-A5; / Immune receptor expressed on myeloid cells 2; / IREM-2; / Polymeric immunoglobulin receptor 2; / PIgR-2; / PIgR2; / Poly-Ig receptor 2; / CD antigen CD300e; / ,CD300e nanobody |
| Species | Human |
| Gene ID | 342510 |
| Uniprot | Q496F6 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed in NK cell subsets (at protein level) (PubMed:21825173, PubMed:94322, PubMed:948526). Expressed in memory/effector CD8-positive alpha-beta T cell subsets (at protein level) (PubMed:12387742, PubMed:2952657). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:948526). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:2952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:2952657). |
| Signaling_pathway | |
| Research Areas | |
| Function | Probably acts as an activating receptor.,PTM:N-glycosylated.,similarity:Belongs to the CD300 family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with TYROBP.,tissue specificity:Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level)., |
