Recombinant CD326/EPCAM Fc-Fused Nanobody (VF0556)
Ucallm_WN0296
$365.00
Product details
Background:This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations inThis gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Specifications
| Size | 100μL |
| Target | CD326/EPCAM |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0426 |
| Immunogen | Purified recombinant Human CD326 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD326/EPCAM protein. |
| Gene Name | EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 |
| Protein Name | Epithelial cell adhesion molecule |
| Other Name | 17 1A; / 323/A3; / Adenocarcinoma associated antigen; / Adenocarcinoma-associated antigen; / Antigen identified by monoclonal antibody AUA1; / AUA1; / CD326; / CD326 antigen; / Cell surface glycoprotein Trop 1; / Cell surface glycoprotein Trop 2; / Cell surface glycoprotein Trop-1; / CO 17A; / CO17 1A; / CO17A; / DIAR5; / EGP 2; / EGP; / EGP2; / EGP314; / EGP40; / Ep CAM; / Ep-CAM; / EPCAM; / EPCAM_HUMAN; / Epithelial cell adhesion molecule; / Epithelial Cell Adhesion Molecule Intracellular Domain; / EpCAM-ICD; / Epithelial cell surface antigen; / Epithelial cellular adhesion molecule; / Epithelial glycoprotein 1; / Epithelial glycoprotein 314; / Epithelial glycoprotein; / ESA; / GA733 1; / GA733 2; / GA733-2; / gastrointestinal tumor-associated antigen 2; / 35-KD glycoprotein; / hEGP 2; / hEGP314; / HNPCC8; / Human epithelial glycoprotein 2; / KS 1/4 antigen; / KS1/4; / KSA; / Lymphocyte antigen 74; / M1S 1; / M1S2; / M4S1; / Major gastrointestinal tumor associated protein GA733 2; / Major gastrointestinal tumor-associated protein GA733-2; / Membrane component chromosome 4 surface marker; / 35kD glycoprotein; / Membrane component; / chromosome 4; / surface marker 1; / Membrane component; / chromosome 4; / surface marker; / MIC18; / MK 1; / TACD1; / TACSTD1; / TROP1; / Tumor associated calcium signal transducer 1; / Tumor associated calcium signal transducer 2 precursor; / Tumor-associated calcium signal transducer 1; / CD326 nanobody; / EPCAM nanobody |
| Species | Human |
| Gene ID | 4072 |
| Uniprot | P16422 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Lateral cell membrane; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. . |
| Tissue Expression | Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| Signaling_pathway | |
| Research Areas | |
| Function | Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages., |
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