Recombinant CD337 Fc-Fused Nanobody (VF0362)
Ucallm_WN0318
$365.00
Product details
Background:The p30-15 monoclonal antibody recognizes CD337 also known as activating NK receptor NKp30 (NKp30), and natural cytotoxicity triggering receptor 3. NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on resting and activated NK cells. NKp30 enhances NK cell cytolysis of tumor cellts that are deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ. The p30-15 antibody against human NKp30 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp30 in a redirected lysis assay, and blocking of NKp30 function in solution.
Specifications
| Size | 100μL |
| Target | CD337 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000 |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0017 |
| Immunogen | Purified recombinant Human CD337 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD337 protein. |
| Gene Name | NCR3 1C7 LY117 |
| Protein Name | Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337) |
| Other Name | 1C7 antibody; / Activating natural killer receptor p30 antibody; / Activating NK A1 receptor antibody; / CD337 antibody; / CD337 antigen antibody; / LY117 antibody; / Lymphocyte antigen 117 antibody; / MALS antibody; / Natural cytotoxicity triggering receptor 3 antibody; / Natural killer cell p30 related protein antibody; / Natural killer cell p30-related protein antibody; / Ncr3 antibody; / NCTR3_HUMAN antibody; / NK-p30 antibody; / NKp30 antibody; / CD337 nanobody |
| Species | Human |
| Gene ID | 259197 |
| Uniprot | O14931 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level). |
| Signaling_pathway | Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity |
| Research Areas | |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
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