$365.00
Background:The protein encoded byThis gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells.This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Aug 2011]
| Size | 100μL |
| Target | CD34 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0309 |
| Immunogen | Purified recombinant Human CD34 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD34 protein. |
| Gene Name | CD34 |
| Protein Name | Hematopoietic progenitor cell antigen CD34 (CD antigen CD34) |
| Other Name | CD34 antibody; / CD34 antigen antibody; / CD34 molecule antibody; / CD34_HUMAN antibody; / Cluster designation 34 antibody; / cluster of differentiation 34 antibody; / Hematopoietic progenitor cell antigen CD34 antibody; / HPCA1 antibody; / Mucosialin antibody; / OTTHUMP00000034733 antibody; / OTTHUMP00000034734 antibody; / CD34 nanobody |
| Species | Human |
| Gene ID | 947 |
| Uniprot | P28906 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation. |
| Signaling_pathway | Organismal Systems >> Immune system >> Hematopoietic cell lineage;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | Alternative products:Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation,developmental stage:On early hematopoietic progenitor cells.,Disease:Abnormal CD34 expression in leukemogenesis.,Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.,online information:CD34 entry,PTM:Highly glycosylated.,PTM:Phosphorylated on serine residues by PKC.,similarity:Belongs to the CD34 family.,tissue specificity:Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues., |
