Recombinant CD45 Fc-Fused Nanobody (VF0540)
Ucallm_WN0370
$365.00
Product details
Background:The protein encoded byThis gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation.This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants ofThis gene, which enc
Specifications
| Size | 100μL |
| Target | CD45 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0467 |
| Immunogen | Purified recombinant Human CD45 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD45 protein. |
| Gene Name | PTPRC CD45 |
| Protein Name | Receptor-type tyrosine-protein phosphatase C (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) |
| Other Name | B220 antibody; / CD 45 antibody; / CD45 antibody; / CD45 antigen antibody; / CD45R antibody; / GP180 antibody; / L-CA antibody; / LCA antibody; / Leukocyte common antigen antibody; / loc antibody; / Ly-5 antibody; / LY5 antibody; / Ly5; / homolog of antibody; / Lyt-4 antibody; / OTTHUMP00000033813 antibody; / OTTHUMP00000033816 antibody; / OTTHUMP00000033817 antibody; / OTTHUMP00000038574 antibody; / Protein tyrosine phosphatase receptor type c polypeptide antibody; / Protein tyrosine phosphatase; / receptor type C antibody; / protein tyrosine phosphatase; / receptor type; / C antibody; / Protein tyrosine phosphatase; / receptor type; / c polypeptide antibody; / Ptprc antibody; / PTPRC_HUMAN antibody; / Receptor-type tyrosine-protein phosphatase C antibody; / T200 antibody; / T200 glycoprotein antibody; / T200 leukocyte common antigen antibody; / CD45 nanobody |
| Species | Human |
| Gene ID | 5788 |
| Uniprot | P08575 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts. . |
| Tissue Expression | [Isoform p41]: In B cells, represents 1% of total CD74 expression.; [Isoform p33]: In B cells, represents 7% of total CD74 expression. |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | Alternative products:At least 8 isoforms are produced,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Disease:Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.,Disease:Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.,Domain:The first PTPase domain interacts with SKAP1.,Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.,online information:CD45 entry,online information:PTPRC mutation db,PTM:Heavily N- and O-glycosylated.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 tyrosine-protein phosphatase domains.,subunit:Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1., |
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