Recombinant CD57 Fc-Fused Nanobody (VF0351)
Ucallm_WN0421
$365.00
Product details
Background:The protein encoded byThis gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages.This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Specifications
| Size | 100μL |
| Target | CD57 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0529 |
| Immunogen | Purified recombinant Human CD57 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD57 protein. |
| Gene Name | B3GAT1 GLCATP |
| Protein Name | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P) |
| Other Name | B3GAT1; / GLCATP; / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; / Beta-1; / 3-glucuronyltransferase 1; / Glucuronosyltransferase P; / GlcAT-P; / UDP-GlcUA:glycoprotein beta-1; / 3-glucuronyltransferase; / GlcUAT-P; / CD57 nanobody |
| Species | Human |
| Gene ID | 27087 |
| Uniprot | Q9P2W7 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted . |
| Tissue Expression | Detected in platelets (at protein level) (PubMed:1964571). Expressed by a variety of hematopoietic and epithelial cells (PubMed:1964571). |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 43 family.,subunit:Homodimer .,tissue specificity:Mainly expressed in the brain., |
Please login to post questions
Related products
