Recombinant CD72 Fc-Fused Nanobody (VF0234)
Ucallm_WN0501
$365.00
Product details
Background:CD72 is a disulfide-linked homodimer belonging to C-type lectin family. CD72 is a pan-B cell marker expressed on pre-pre-B cells throughout B cell differentiation with the exception of plasma cells. It is also expressed on follicular dendritic cells, splenic red pulp macrophages (but not on peripheral blood monocytes), and liver Kupffer cells. CD72, a negative coreceptor of B cells, contains immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain which has been shown to recruit the tyrosine phosphatase SHP-1. Ligation of CD72 with its ligand regulates CD72 tyrosine dephosphorylation and SHP-1 dissociation to promote B cell activation and proliferation. CD100 and CD5 have been shown to be CD72 ligands. The CD100-CD72 interaction plays a role in maintenance of B cell homeostasis.
Specifications
| Size | 100μL |
| Target | CD72 |
| Reactivity | Human |
| Applications | ELISA, FC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0576 |
| Immunogen | Purified recombinant Human CD72 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD72 protein. |
| Gene Name | CD72 |
| Protein Name | B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72) |
| Other Name | CD72; / B-cell differentiation antigen CD72; / Lyb-2; / CD72; / CD72 nanobody |
| Species | Human |
| Gene ID | 971 |
| Uniprot | P21854 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type II membrane protein. |
| Tissue Expression | [Isoform p41]: In B cells, represents 1% of total CD74 expression.; [Isoform p33]: In B cells, represents 7% of total CD74 expression. |
| Signaling_pathway | Organismal Systems >> Immune system >> B cell receptor signaling pathway |
| Research Areas | |
| Function | Plays a role in B-cell proliferation and differentiation. Associates with CD5.,online information:CD72,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer; disulfide-linked.,tissue specificity:Pre-B-cells and B-cells but not terminally differentiated plasma cells., |
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