Recombinant CD73 Fc-Fused Nanobody (VF0524)
Ucallm_WN0507
$365.00
Product details
Background:The protein encoded byThis gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects inThis gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found forThis gene.[provided by RefSeq, Mar 2011]
Specifications
| Size | 100μL |
| Target | CD73 |
| Reactivity | Human |
| Applications | ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0376 |
| Immunogen | Purified recombinant Human CD73 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD73 protein. |
| Gene Name | NT5E NT5 NTE |
| Protein Name | 5'-nucleotidase (5'-NT) (Ecto-5'-nucleotidase) (CD antigen CD73) |
| Other Name | NT5E; / NT5; / NTE; / 5'-nucleotidase; / 5'-NT; / Ecto-5'-nucleotidase; / CD antigen CD73; / CD73 nanobody |
| Species | Human |
| Gene ID | 4907 |
| Uniprot | P21589 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . |
| Tissue Expression | Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 3 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level) |
| Signaling_pathway | |
| Research Areas | >>Transcriptional misregulation in cancer |
| Function | Catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,Disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked., |
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