Reg Iα Monoclonal Antibody
Ucallm_WM0398-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Reg Iα |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 12B8 |
| Immunogen | Purified recombinant fragment of human Reg Iα fused with hIgGFc tag expressed in HEK293 cell line. |
| Specificity | Reg Iα Monoclonal Antibody detects endogenous levels of Reg Iα protein. |
| Gene Name | REG1A |
| Protein Name | Lithostathine-1-alpha |
| Other Name | REG1A; / PSPS; / PSPS1; / REG; / Lithostathine-1-alpha; / Islet cells regeneration factor; / ICRF; / Islet of Langerhans regenerating protein; / REG; / Pancreatic stone protein; / PSP; / Pancreatic thread protein; / PTP; / Regenerating islet-derived protein 1-alpha |
| Species | Human |
| Gene ID | 5967 |
| Uniprot | P05451 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients. |
| Signaling_pathway | |
| Research Areas | |
| Function | Caution:The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.,developmental stage:High expression levels in fetal and infant brains; much lower in adult brains.,Disease:Alzheimer disease and Down syndrome patients show enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins in their brains.,Function:Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.,online information:Lithostathine A,similarity:Contains 1 C-type lectin domain.,tissue specificity:In pancreatic acinar cells and, in lower levels, in brain., |
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