Product details
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RGS2 rabbit pAb
Ucallm_WP6498-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RGS2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 23kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RGS2 |
| Specificity | This antibody detects endogenous levels of RGS2 at Human, Mouse,Rat |
| Gene Name | RGS2 G0S8 GIG31 |
| Protein Name | Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8) |
| Other Name | |
| Species | Human |
| Gene ID | 5997 |
| Uniprot | P41220, |
| Species.1 | Mouse |
| Gene ID.1 | 19735 |
| Uniprot.1 | O08849, |
| Species.2 | Rat |
| Gene ID.2 | 84583 |
| Uniprot.2 | Q9JHX0 |
| Cellular Localization | [Isoform 1]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 2]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 3]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 4]: Cell membrane . Mitochondrion . |
| Tissue Expression | Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . It is involved in the negative regulation of the angiotensin-activated signaling pathway . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein . |
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