Product details
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RHBDD1 rabbit pAb
Ucallm_WP6613-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RHBDD1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 35kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RHBDD1 |
| Specificity | This antibody detects endogenous levels of RHBDD1 at Human, Mouse,Rat |
| Gene Name | RHBDD1 RHBDL4 HSD-50 HSD50 |
| Protein Name | Rhomboid-related protein 4 (RRP4) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4) |
| Other Name | |
| Species | Human |
| Gene ID | 84236 |
| Uniprot | Q8TEB9, |
| Species.1 | Mouse |
| Gene ID.1 | 76867 |
| Uniprot.1 | Q8BHC7, |
| Species.2 | Rat |
| Gene ID.2 | 316557 |
| Uniprot.2 | Q4V8F3 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . Mitochondrion membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed strongly in testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. |
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