Price range: $268.00 through $328.00
Background:
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],
| Target | Rictor |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IHC, IF, FC, ELISA |
| MW(Calculated) | 192kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | Affinity purification |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 20B4 |
| Immunogen | Purified recombinant fragment of human Rictor expressed in E. Coli. |
| Sequence | |
| Specificity | Rictor Monoclonal Antibody detects endogenous levels of Rictor protein. |
| Gene Name | RICTOR |
| Protein Name | Rapamycin-insensitive companion of mTOR |
| Other Name | RICTOR; / KIAA1999; / Rapamycin-insensitive companion of mTOR; / AVO3 homolog; / hAVO3 |
| Species | Human |
| Gene ID-1 | 253260 |
| Uniprot | Q6R327, |
| Species.1 | Mouse |
| Gene ID-2 | 78757 |
| Uniprot.1 | Q6QI06 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008], |
| Cellular Localization | cytosol,TORC2 complex, |
| Tissue Expression | Amygdala,Brain,Epithelium,Lymph, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>mTOR signaling pathway |
| Function | Function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2., |
| RRID |
