Product details
Background:
RNF128 rabbit pAb
Ucallm_WP7512-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RNF128 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 47kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RNF128 |
| Specificity | This antibody detects endogenous levels of RNF128 at Human, Mouse |
| Gene Name | RNF128 GRAIL |
| Protein Name | E3 ubiquitin-protein ligase RNF128 (Gene related to anergy in lymphocytes protein) (RING finger protein 128) |
| Other Name | |
| Species | Human |
| Gene ID | 79589 |
| Uniprot | Q8TEB7, |
| Species.1 | Mouse |
| Gene ID.1 | 66889 |
| Uniprot.1 | Q9D304 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endomembrane system; Single-pass membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. |
Please login to post questions
Related products
