RNF40 rabbit pAb
Ucallm_WP8331-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | RNF40 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 110kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RNF40 |
| Specificity | This antibody detects endogenous levels of RNF40 at Human, Mouse,Rat |
| Gene Name | RNF40 BRE1B KIAA0661 |
| Protein Name | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) |
| Other Name | |
| Species | Human |
| Gene ID | 9810 |
| Uniprot | O75150, |
| Species.1 | Mouse |
| Gene ID.1 | 233900 |
| Uniprot.1 | Q3U319, |
| Species.2 | Rat |
| Gene ID.2 | 266712 |
| Uniprot.2 | Q8CJB9 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. |
| Signaling_pathway | |
| Research Areas | |
| Function | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. |
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