ROBO1 Polyclonal Antibody
Ucallm_WP1666-50
Price range: $268.00 through $328.00
Product details
Background:
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
Specifications
| Size | 50μL/100μL |
| Target | ROBO1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 181kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 730-810 |
| Specificity | ROBO1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ROBO1 DUTT1 |
| Protein Name | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) |
| Other Name | |
| Species | Human |
| Gene ID | 6091 |
| Uniprot | Q9Y6N7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O89026, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O55005 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell projection, axon . Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass membrane protein . Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity). . |
| Tissue Expression | Widely expressed, with exception of kidney. |
| Signaling_pathway | |
| Research Areas | >>Axon guidance |
| Function | Disease:Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.,Function:Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.,similarity:Belongs to the immunoglobulin superfamily. ROBO family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with SLIT1 and SLIT2.,tissue specificity:Widely expressed, with exception of kidney., |
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