SKU: WP17049 Categories: ,

ROP1A rabbit pAb

Price range: $268.00 through $328.00

SKU: WP17049-100
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Product details

Background:

The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015],

Specifications

Size50μL/100μL
TargetROP1A
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC
MW(Calculated)23kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ROP1A AA range: 85-135
SpecificityThis antibody detects endogenous levels of ROP1A at Human
Gene NameROPN1 ROPN1A
Protein NameROP1A
Other Name
SpeciesHuman
Gene ID54763
UniprotQ9HAT0
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell projection, cilium, flagellum . In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. .
Tissue ExpressionTestis specific in adult. Overexpressed in hematologic tumor cells.
Signaling_pathway
Research Areas
Functiondevelopmental stage:Expressed in fetal liver.,Domain:The RIIa domain mediates interaction with AKAP3.,miscellaneous:The name 'ropporin' comes from the Japanese word 'oppo' which means 'tail'.,similarity:Belongs to the ropporin family.,similarity:Contains 1 RIIa domain.,subcellular location:In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.,subunit:Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.,tissue specificity:Testis specific in adult. Overexpressed in hematologic tumor cells.,
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