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RORγ Polyclonal Antibody
Ucallm_WP14364-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | RORγ |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 58kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RORG. AA range:71-120 |
| Specificity | RORγ Polyclonal Antibody detects endogenous levels of RORγ protein. |
| Gene Name | RORC |
| Protein Name | Nuclear receptor ROR-gamma |
| Other Name | RORC; / NR1F3; / RORG; / RZRG; / Nuclear receptor ROR-gamma; / Nuclear receptor RZR-gamma; / Nuclear receptor subfamily 1 group F member 3; / Retinoid-related orphan receptor-gamma |
| Species | Human |
| Gene ID | 6097 |
| Uniprot | P51449, |
| Species.1 | Mouse |
| Gene ID.1 | 19885 |
| Uniprot.1 | P51450 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Environmental adaptation >> Circadian rhythm;Human Diseases >> Immune disease >> Inflammatory bowel disease |
| Research Areas | >>Th17 cell differentiation; / >>Circadian rhythm; / >>Inflammatory bowel disease |
| Function | Function:Orphan nuclear receptor.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Highly expressed in skeletal muscle., |
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