SKU: WP1424 Categories: ,

RORB Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1424-100
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Product details

Background:

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014],

Specifications

Size50μL/100μL
TargetRORB
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)51kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 210-290
SpecificityRORB Polyclonal Antibody detects endogenous levels of protein.
Gene NameRORB NR1F2 RZRB
Protein NameNuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
Other Name
SpeciesHuman
Gene ID6096
UniprotQ92753,
Species.1Mouse
Gene ID.1
Uniprot.1Q8R1B8,
Species.2Rat
Gene ID.2
Uniprot.2P45446
Cellular LocalizationNucleus, nucleoplasm .
Tissue ExpressionBrain,Cerebellum,Eye,Retina,
Signaling_pathwayOrganismal Systems >> Environmental adaptation >> Circadian rhythm
Research Areas>>Circadian rhythm
FunctionFunction:Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,
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