RPA70 mouse mAb
Ucallm_WM0690-50
Price range: $268.00 through $328.00
Product details
Background:
function:It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the replication factor A protein 1 family., subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4.,
Specifications
| Size | 50μL/100μL |
| Target | RPA70 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, ICC, IP |
| MW(Calculated) | |
| MW(Observed) | 70kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 3F1 |
| Immunogen | Purified recombinant human RPA70 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of RPA70 and does not cross-react with related proteins. |
| Gene Name | RPA1 REPA1 RPA70 |
| Protein Name | Replication protein A 70 kDa DNA-binding subunit |
| Other Name | Dmrpa1; / Drosophila Replication Protein A; / DRPA; / DSSB; / HSSB; / Human single stranded DNA binding protein; / MST075; / MSTP075; / p70; / REPA 1; / REPA1; / Replication factor A; / Replication factor A protein 1; / Replication protein A 70 kDa DNA-binding subunit; / Replication protein A 70kDa DNA binding subunit; / Replication protein A1; / 70kD; / Replication protein A1; / 70kD; / Replication protein A1 70kDa; / Replication protein A1; / RF A; / RF-A protein 1; / RFA; / RFA1_HUMAN; / RP A; / RP-A p70; / RPA 1; / RPA 70; / RPA; / RPA1; / Single stranded binding protein 70; / Single stranded DNA binding protein; / Single-stranded DNA-binding protein; / Ssb70. |
| Species | Human |
| Gene ID | 6117 |
| Uniprot | P27694, |
| Species.1 | Mouse |
| Gene ID.1 | 68275 |
| Uniprot.1 | Q8VEE4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Nucleus, PML body . Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. . |
| Tissue Expression | Aorta,Aortic endothelium,Lung carcinoma,Uterus, |
| Signaling_pathway | |
| Research Areas | >>DNA replication; / >>Nucleotide excision repair; / >>Mismatch repair; / >>Homologous recombination; / >>Fanconi anemia pathway |
| Function | Function:It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the replication factor A protein 1 family.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4., |
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