RPIA rabbit pAb
Ucallm_WP16848-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010],
Specifications
| Size | 50μL/100μL |
| Target | RPIA |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 34kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RPIA AA range: 256-306 |
| Specificity | This antibody detects endogenous levels of RPIA at Human/Mouse |
| Gene Name | RPIA RPI |
| Protein Name | RPIA |
| Other Name | |
| Species | Human |
| Gene ID | 22934 |
| Uniprot | P49247, |
| Species.1 | Mouse |
| Gene ID.1 | 19895 |
| Uniprot.1 | P47968 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytosol,integral component of membrane,intracellular membrane-bounded organelle, |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Pentose phosphate pathway; / >>Metabolic pathways; / >>Carbon metabolism; / >>Biosynthesis of amino acids |
| Function | Catalytic activity:D-ribose 5-phosphate = D-ribulose 5-phosphate.,Disease:Defects in RPIA are the cause of ribose 5-phosphate isomerase deficiency [MIM:608611]. A patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.,similarity:Belongs to the ribose 5-phosphate isomerase family., |
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