Product details
Background:
RRP1B rabbit pAb
Ucallm_WP8651-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RRP1B |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 83kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RRP1B |
| Specificity | This antibody detects endogenous levels of RRP1B at Human, Mouse |
| Gene Name | RRP1B KIAA0179 |
| Protein Name | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) |
| Other Name | |
| Species | Human |
| Gene ID | 23076 |
| Uniprot | Q14684, |
| Species.1 | Mouse |
| Gene ID.1 | 72462 |
| Uniprot.1 | Q91YK2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleolus . Nucleus, nucleoplasm . Chromosome . Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015). .; Nucleus, nucleoplasm . (Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 . Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus . Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure .; (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. |
Please login to post questions
Related products
