Product details
Background:
RRP44 rabbit pAb
Ucallm_WP3657-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RRP44 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RRP44 AA range: 262-312 |
| Specificity | This antibody detects endogenous levels of RRP44 at Human/Mouse |
| Gene Name | DIS3 KIAA1008 RRP44 |
| Protein Name | RRP44 |
| Other Name | Exosome complex exonuclease RRP44; / EC 3.1.26.-; / Protein DIS3 homolog; / Ribosomal RNA-processing protein 44 |
| Species | Human |
| Gene ID | 22894 |
| Uniprot | Q9Y2L1, |
| Species.1 | Mouse |
| Gene ID.1 | 72662 |
| Uniprot.1 | Q9CSH3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus . Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> RNA degradation |
| Research Areas | >>RNA degradation |
| Function | Function:Component of the exosome 3'->5' exoribonuclease complex. Required for the 3'-processing of the 7S pre-RNA to the mature nuclear complex. Also associated with the GTPase Ran. Has a 3'-5' exonuclease activity.,similarity:Belongs to the ribonuclease II (RNB) family.,similarity:Contains 1 PINc domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: RRP4, RRP40, RRP41/SKI6, RRP42, RRP43, RRP44/DIS3, PM/Scl-75, RRP46, CSL4 and PM/Scl-100 (only in the nuclear complex). Also associated with the GTPase Ran.,tissue specificity:Widely expressed., |
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