Name: Rsk-2 Monoclonal Antibody
SKU: WM0406
Price: 268 USD
Availability: InStock

Product details

Background:
ribosomal protein S6 kinase A3(RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008],

Specifications

Target	RSK2
Reactivity	Human
Applications	WB, IF, FC, ELISA
MW(Calculated)	84kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	Affinity purification
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	16G12
Immunogen	Purified recombinant fragment of human Rsk-2 expressed in E. Coli.
Sequence
Specificity	Rsk-2 Monoclonal Antibody detects endogenous levels of Rsk-2 protein.
Gene Name	RPS6KA3 ISPK1 MAPKAPK1B RSK2
Protein Name	Ribosomal protein S6 kinase alpha-3
Other Name	Ribosomal protein S6 kinase alpha-3; / S6K-alpha-3; / 90 kDa ribosomal protein S6 kinase 3; / p90-RSK 3; / p90RSK3; / Insulin-stimulated protein kinase 1; / ISPK-1; / MAP kinase-activated protein kinase 1b; / MAPK-activated protein kinase 1b; / MAPKAP kinase 1b; / MAPKAPK-1b; / Ribosomal S6 kinase 2; / RSK-2; / pp90RSK2
Species	Human
Gene ID-1	6197
Uniprot	P51812,
Species.1	Mouse
Gene ID-2	110651
Uniprot.1	P18654
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	ribosomal protein S6 kinase A3(RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008],
Cellular Localization	Nucleus . Cytoplasm .
Tissue Expression	Expressed in many tissues, highest levels in skeletal muscle.
Signaling_pathway	Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas	>>MAPK signaling pathway; / >>Oocyte meiosis; / >>mTOR signaling pathway; / >>Thermogenesis; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Insulin resistance; / >>Yersinia infection; / >>Chemical carcinogenesis - receptor activation
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Disease:Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-386, as part of the activation process.,PTM:Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4.,tissue specificity:Expressed in many tissues, highest levels in skeletal muscle.,
RRID