Price range: $268.00 through $328.00
Background:
ribosomal protein S6 kinase A6(RPS6KA6) Homo sapiens This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010],
| Size | 50μL/100μL |
| Target | Rsk-4 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 84kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human S6K-alpha6. AA range:661-710 |
| Specificity | Rsk-4 Polyclonal Antibody detects endogenous levels of Rsk-4 protein. |
| Gene Name | RPS6KA6 |
| Protein Name | Ribosomal protein S6 kinase alpha-6 |
| Other Name | RPS6KA6; / RSK4; / Ribosomal protein S6 kinase alpha-6; / S6K-alpha-6; / 90 kDa ribosomal protein S6 kinase 6; / p90-RSK 6; / p90RSK6; / Ribosomal S6 kinase 4; / RSK-4; / pp90RSK4 |
| Species | Human |
| Gene ID | 27330 |
| Uniprot | Q9UK32, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TPS0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytosol . Nucleus . Predominantly cytosolic. |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Oocyte meiosis; / >>mTOR signaling pathway; / >>Thermogenesis; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Insulin resistance; / >>Yersinia infection; / >>Chemical carcinogenesis - receptor activation |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-389, as part of the activation process.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation., |
