Product details
Background:
RyDEN rabbit pAb
Ucallm_WP6815-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SHFL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 32kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RyDEN |
| Specificity | This antibody detects endogenous levels of RyDEN at Human, Mouse,Rat |
| Gene Name | C19orf66 |
| Protein Name | UPF0515 protein C19orf66 |
| Other Name | |
| Species | Human |
| Gene ID | 55337 |
| Uniprot | Q9NUL5, |
| Species.1 | Mouse |
| Gene ID.1 | 319278 |
| Uniprot.1 | Q8CAK3, |
| Species.2 | Rat |
| Gene ID.2 | 500956 |
| Uniprot.2 | Q5RJN4 |
| Cellular Localization | Cytoplasm . Nucleus . Cytoplasm, P-body . Predominantly found in the cytoplasm (PubMed:26735137). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site . Regulates HIV1 GAG-POL expression by inhibiting -1PRF . Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Interrupts also Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway . Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus . Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA .; Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. |
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