Product details
Background:
RYR1 rabbit pAb
Ucallm_WP7751-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | RYR1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 554kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human RYR1 |
| Specificity | This antibody detects endogenous levels of RYR1 at Human, Mouse,Rat |
| Gene Name | RYR1 RYDR |
| Protein Name | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) |
| Other Name | |
| Species | Human |
| Gene ID | 6261 |
| Uniprot | P21817, |
| Species.1 | Mouse |
| Gene ID.1 | 20190 |
| Uniprot.1 | E9PZQ0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | F1LMY4 |
| Cellular Localization | Sarcoplasmic reticulum membrane; Multi-pass membrane protein . Sarcoplasmic reticulum . The number of predicted transmembrane domains varies between orthologs, but the 3D-structures show the presence of six transmembrane regions. Both N-terminus and C-terminus are cytoplasmic. . |
| Tissue Expression | Skeletal muscle and brain (cerebellum and hippocampus). |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | |
| Function | Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules . Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm . Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). |
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