S28A1 Polyclonal Antibody
Ucallm_WP1762-50
Price range: $268.00 through $328.00
Product details
Background:
function:Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3′-azido-3′-deoxythymidine (AZT) and 2′, 3′-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine., polymorphism:Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity., similarity:Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family., tissue specificity:Expressed in kidney.,
Specifications
| Size | 50μL/100μL |
| Target | S28A1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 71kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | S28A1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SLC28A1 CNT1 |
| Protein Name | Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1) |
| Other Name | |
| Species | Human |
| Gene ID | 9154 |
| Uniprot | O00337, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q62674 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.,polymorphism:Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity.,similarity:Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.,tissue specificity:Expressed in kidney., |
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