Price range: $268.00 through $328.00
Background:
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008],
| Size | 50μL/100μL |
| Target | S29A2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | S29A2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SLC29A2 DER12 ENT2 HNP36 |
| Protein Name | Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2) |
| Other Name | |
| Species | Human |
| Gene ID | 3177 |
| Uniprot | Q14542, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q61672, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O54699 |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein . Nucleus membrane; Multi-pass membrane protein . Localized at the basolateral cell membrane in polarized MDCK cells. |
| Tissue Expression | Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. |
| Signaling_pathway | |
| Research Areas | >>Alcoholism |
| Function | Function:Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.,induction:By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).,similarity:Belongs to the SLC29A transporter family.,tissue specificity:Expressed in placenta, brain, heart and ovarian tissues., |
