Name: S4A5 rabbit pAb
SKU: WP16263
Price: 268 USD
Availability: InStock

S4A5 rabbit pAb

Ucallm_WP16263-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP16263-100

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Product details

Background:

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	S4A5
Reactivity	Human, Rat
Applications	WB
MW(Calculated)	125kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human S4A5 AA range: 26-76
Specificity	This antibody detects endogenous levels of S4A5 at Human/Rat
Gene Name	SLC4A5 NBC4
Protein Name	S4A5
Other Name
Species	Human
Gene ID	57835
Uniprot	Q9BY07,
Species.1
Gene ID.1
Uniprot.1
Species.2	Rat
Gene ID.2	297386
Uniprot.2	Q6RI88
Cellular Localization	Apical cell membrane; Multi-pass membrane protein . Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. .
Tissue Expression	Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.
Signaling_pathway
Research Areas	>>Bile secretion
Function	Function:Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anionic channels and transporters).,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,subcellular location:Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.,tissue specificity:Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.,