Price range: $268.00 through $328.00
Background:
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011],
| Target | SHRM3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 220kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SHRM3 AA range: 777-827 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of SHRM3 at Human/Mouse |
| Gene Name | SHROOM3 KIAA1481 SHRML MSTP013 |
| Protein Name | SHRM3 |
| Other Name | |
| Species | Human |
| Gene ID-1 | 57619 |
| Uniprot | Q8TF72, |
| Species.1 | Mouse |
| Gene ID-2 | 27428 |
| Uniprot.1 | Q9QXN0 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011], |
| Cellular Localization | Cell junction, adherens junction . Cytoplasm, cytoskeleton . Apical cell membrane; Peripheral membrane protein . Colocalizes with F-actin in stress fibers and adherens junctions. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The ASD1 domain mediates F-actin binding.,Domain:The ASD2 domain is required for apical constriction induction.,Function:Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.,similarity:Belongs to the shroom family.,similarity:Contains 1 ASD1 domain.,similarity:Contains 1 ASD2 domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with F-actin in stress fibers and adherens junctions.,subunit:Interacts with F-actin., |
| RRID |
