Product details
Background:
SIN3A rabbit pAb
Ucallm_WP6941-50
Price range: $268.00 through $328.00
Specifications
| Target | SIN3A |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 140kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SIN3A |
| Sequence | |
| Specificity | This antibody detects endogenous levels of SIN3A at Human, Mouse |
| Gene Name | SIN3A |
| Protein Name | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 25942 |
| Uniprot | Q96ST3, |
| Species.1 | Mouse |
| Gene ID-2 | 20466 |
| Uniprot.1 | Q60520 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Nucleus . Nucleus, nucleolus . Recruited to the nucleolus by SAP30L. |
| Tissue Expression | Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Neurodegenerative disease >> Huntington disease;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway |
| Research Areas | |
| Function | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). |
| RRID |
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