Product details
Background:
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SLC40A1 rabbit pAb
Ucallm_WP9009-50
Price range: $268.00 through $328.00
Specifications
| Target | SLC40A1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 63kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SLC40A1. AA range 1-100 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of SLC40A1 at Human, Mouse,Rat |
| Gene Name | SLC40A1 FPN1 IREG1 SLC11A3 MSTP079 |
| Protein Name | Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 30061 |
| Uniprot | Q9NP59, |
| Species.1 | Mouse |
| Gene ID-2 | 53945 |
| Uniprot.1 | Q9JHI9, |
| Species.2 | Rat |
| Gene ID-3 | 170840 |
| Uniprot.2 | Q923U9 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Localized to the basolateral membrane of polarized epithelial cells. |
| Tissue Expression | Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Ferroptosis |
| Research Areas | |
| Function | Major iron transporter that plays a key role in balancing cellular and systemic iron levels . Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma . |
| RRID |
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