Name: SLUG Monoclonal Antibody
SKU: WM0420
Price: 268 USD
Availability: InStock

SLUG Monoclonal Antibody

Ucallm_WM0420-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM0420-50

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Product details

Background:
snail family transcriptional repressor 2(SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	SLUG
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)	30kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	16H3
Immunogen	Purified recombinant fragment of human SLUG expressed in E. Coli.
Specificity	SLUG Monoclonal Antibody detects endogenous levels of SLUG protein.
Gene Name	SNAI2 SLUG SLUGH
Protein Name	Zinc finger protein SNAI2
Other Name	SNAI2; / SLUG; / SLUGH; / Zinc finger protein SNAI2; / Neural crest transcription factor Slug; / Protein snail homolog 2
Species	Human
Gene ID	6591
Uniprot	O43623
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Cytoplasm. Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Tissue Expression	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Research Areas	>>Hippo signaling pathway; / >>Adherens junction
Function	Disease:Defects in SNAI2 are a cause of neural tube defects (NTD).,Disease:Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.,Function:Transcriptional repressor. Involved in the generation and migration of neural crest cells.,similarity:Belongs to the snail C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.,

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SLUG Monoclonal Antibody

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SLUG Monoclonal Antibody

Product details

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