Smad1/9 [PTR2351] mouse mAb
Ucallm_WM1352-50
Price range: $268.00 through $328.00
Product details
Background:
SMAD family member 1(SMAD1) Homo sapiens The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-med
Specifications
| Size | 50μL/100μL |
| Target | SMAD1/9 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 58-60kD |
| Host Species | Mouse |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMR2351 |
| Immunogen | Synthesized peptide derived from human Smad1/9 AA range: 400-465 |
| Specificity | This antibody detects endogenous levels of Smad1/9 protein. |
| Gene Name | SMAD1 SMAD9 |
| Protein Name | Mothers against decapentaplegic homolog 1 (MAD homolog 1/9) (Mothers against DPP homolog 1/9) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1/9) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) |
| Other Name | |
| Species | Human |
| Gene ID | 4086 |
| Uniprot | Q15797;O15198, |
| Species.1 | Mouse |
| Gene ID.1 | 17125 |
| Uniprot.1 | P70340 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | |
| Tissue Expression | Ubiquitous. Highest expression seen in the heart and skeletal muscle. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway |
| Research Areas | |
| Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. |
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