sMtCK Monoclonal Antibody
Ucallm_WM0536-50
Price range: $268.00 through $328.00
Product details
Background:
creatine kinase, mitochondrial 2(CKMT2) Homo sapiens Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gen
Specifications
| Size | 50μL/100μL |
| Target | sMtCK |
| Reactivity | Human, Mouse, Rat, Dog, Pig |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-1:2000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 18G5 |
| Immunogen | Purified recombinant human sMtCK protein fragments expressed in E.coli. |
| Specificity | sMtCK Monoclonal Antibody detects endogenous levels of sMtCK protein. |
| Gene Name | CKMT2 |
| Protein Name | Creatine kinase S-type mitochondrial |
| Other Name | CKMT2; / Creatine kinase S-type; / mitochondrial; / Basic-type mitochondrial creatine kinase; / Mib-CK; / Sarcomeric mitochondrial creatine kinase; / S-MtCK |
| Species | Human |
| Gene ID | 1160 |
| Uniprot | P17540, |
| Species.1 | Mouse |
| Gene ID.1 | 76722 |
| Uniprot.1 | Q6P8J7, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P09605 |
| Cellular Localization | Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. |
| Tissue Expression | Sarcomere-specific. Found only in heart and skeletal muscles. |
| Signaling_pathway | |
| Research Areas | >>Arginine and proline metabolism; / >>Metabolic pathways |
| Function | Catalytic activity:ATP + creatine = ADP + phosphocreatine.,Function:Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.,miscellaneous:Mitochondrial creatine kinase binds cardiolipin.,similarity:Belongs to the ATP:guanido phosphotransferase family.,subunit:Exists as an octamer composed of four CKMT2 homodimers.,tissue specificity:Sarcomere-specific. Found only in heart and skeletal muscles., |
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