SNX5 Polyclonal Antibody
Ucallm_WP1776-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013],
Specifications
| Size | 50μL/100μL |
| Target | SNX5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SNX5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SNX5 |
| Protein Name | Sorting nexin-5 |
| Other Name | |
| Species | Human |
| Gene ID | 27131 |
| Uniprot | Q9Y5X3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9D8U8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | B1H267 |
| Cellular Localization | Endosome . Early endosome . Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. . |
| Tissue Expression | Brain,Lymph,Ovarian carcinoma,Placenta,Synovial membrane, |
| Signaling_pathway | |
| Research Areas | >>Endocytosis |
| Function | Function:May be involved in several stages of intracellular trafficking.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain., |
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