Price range: $268.00 through $328.00
Background:
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | SO4C1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 80kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SO4C1 AA range: 77-127 |
| Specificity | This antibody detects endogenous levels of SO4C1 at Human/Mouse/Rat |
| Gene Name | SLCO4C1 OATP4C1 OATPX SLC21A20 |
| Protein Name | SO4C1 |
| Other Name | |
| Species | Human |
| Gene ID | 353189 |
| Uniprot | Q6ZQN7, |
| Species.1 | Mouse |
| Gene ID.1 | 227394 |
| Uniprot.1 | Q8BGD4, |
| Species.2 | Rat |
| Gene ID.2 | 432363 |
| Uniprot.2 | Q71MB6 |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein . Detected at the basolateral membrane of the proximal tubule cell in the kidney. . |
| Tissue Expression | Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.,miscellaneous:SLCO4C1-mediated digoxin uptake is inhibited by digoxin itself and related compounds such as ouabain, digitoxin and digoxigenin.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,subcellular location:Detected at the basolateral membrane of the proximal tubule cell in the kidney.,tissue specificity:Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney., |
