SP-A Polyclonal Antibody
Ucallm_WP15268-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | SP-A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 34kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SFTPA1/2. AA range:141-190 |
| Specificity | SP-A Polyclonal Antibody detects endogenous levels of SP-A protein. |
| Gene Name | SFTPA2/SFTPA1 |
| Protein Name | Pulmonary surfactant-associated protein A2/Pulmonary surfactant-associated protein A1 |
| Other Name | SFTPA2; / COLEC5; / PSAP; / SFTP1; / SFTPA; / SFTPA2B; / Pulmonary surfactant-associated protein A2; / PSP-A; / PSPA; / SP-A; / SP-A2; / 35 kDa pulmonary surfactant-associated protein; / Alveolar proteinosis protein; / Collectin-5; / SFTPA1; / COLEC4; / PSAP; / SFTP1; / SFTPA; / SFTPA1B; / Pulmonary surfactant-associated protein A1; / PSP-A; / PSPA; / SP-A; / SP-A1; / 35 kDa pulmonary surfactant-associated protein; / Alveolar proteinosis protein; / Collectin-4 |
| Species | Human |
| Gene ID | 729238 |
| Uniprot | Q8IWL1, |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 24773 |
| Uniprot.2 | P08427 |
| Cellular Localization | Secreted . Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome |
| Research Areas | >>Phagosome; / >>Pertussis |
| Function | Function:In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.,miscellaneous:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).,polymorphism:At least 6 alleles of SFTPA2 are known: 1A, 1A(0), 1A(1), 1A(2), 1A(3) and 1A(4). The sequence shown is that of allele 1A(0).,similarity:Belongs to the SFTPA family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers., |
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