Product details
Background:
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SPIB rabbit pAb
Ucallm_WP7239-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SPIB |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 29kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SPIB |
| Specificity | This antibody detects endogenous levels of SPIB at Human, Mouse,Rat |
| Gene Name | SPIB |
| Protein Name | Transcription factor Spi-B |
| Other Name | |
| Species | Human |
| Gene ID | 6689 |
| Uniprot | Q01892, |
| Species.1 | Mouse |
| Gene ID.1 | 272382 |
| Uniprot.1 | O35906, |
| Species.2 | Rat |
| Gene ID.2 | 499146 |
| Uniprot.2 | Q5EBA3 |
| Cellular Localization | [Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm . |
| Tissue Expression | Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. |
| Signaling_pathway | |
| Research Areas | |
| Function | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. |
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