Product details
Background:
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SPIRE2 rabbit pAb
Ucallm_WP7292-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SPIRE2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 79kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SPIRE2 |
| Specificity | This antibody detects endogenous levels of SPIRE2 at Human, Mouse |
| Gene Name | SPIRE2 KIAA1832 SPIR2 |
| Protein Name | Protein spire homolog 2 (Spir-2) |
| Other Name | |
| Species | Human |
| Gene ID | 84501 |
| Uniprot | Q8WWL2, |
| Species.1 | Mouse |
| Gene ID.1 | 234857 |
| Uniprot.1 | Q8K1S6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytoplasm, cytosol . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . |
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