SKU: WP2805 Categories: ,

SPON1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2805-100
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Product details

Background:

function:Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell., similarity:Contains 1 reelin domain., similarity:Contains 1 spondin domain., similarity:Contains 6 TSP type-1 domains., subunit:Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP., tissue specificity:Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.,

Specifications

Size50μL/100μL
TargetSPON1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)88kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 210-290
SpecificitySPON1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSPON1 KIAA0762 VSGP
Protein NameSpondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)
Other Name
SpeciesHuman
Gene ID10418
UniprotQ9HCB6,
Species.1Mouse
Gene ID.1
Uniprot.1Q8VCC9,
Species.2Rat
Gene ID.2
Uniprot.2P35446
Cellular LocalizationSecreted, extracellular space, extracellular matrix .
Tissue ExpressionHighest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.
Signaling_pathway
Research Areas
FunctionFunction:Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.,similarity:Contains 1 reelin domain.,similarity:Contains 1 spondin domain.,similarity:Contains 6 TSP type-1 domains.,subunit:Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.,tissue specificity:Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.,
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