SR-3A Polyclonal Antibody
Ucallm_WP14570-50
Price range: $268.00 through $328.00
Product details
Background:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | SR-3A |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 5-HT-3A. AA range:161-210 |
| Specificity | SR-3A Polyclonal Antibody detects endogenous levels of SR-3A protein. |
| Gene Name | HTR3A |
| Protein Name | 5-hydroxytryptamine receptor 3A |
| Other Name | HTR3A; / 5HT3R; / HTR3; / 5-hydroxytryptamine receptor 3A; / 5-HT3-A; / 5-HT3A; / 5-hydroxytryptamine receptor 3; / 5-HT-3; / 5-HT3R; / Serotonin receptor 3A; / Serotonin-gated ion channel receptor |
| Species | Human |
| Gene ID | 3359 |
| Uniprot | P46098, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P23979 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. |
| Signaling_pathway | |
| Research Areas | >>Serotonergic synapse; / >>Taste transduction |
| Function | Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.,miscellaneous:The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex are functional but exhibit low conductance, decreased agonist and antagonist affinity with modified voltage dependence. Interacts with RIC3.,tissue specificity:Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta., |
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